automated flash chromatography (Teledyne LABS)
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Teledyne LABS
automated flash chromatography
Automated Flash Chromatography, supplied by Teledyne LABS, used in various techniques. Bioz Stars score: 96/100, based on 371 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/flash+chromatography/CombiFlash+NextGen/pm42045545-235-0-9
Average 96 stars, based on 371 article reviews
Automated Flash Chromatography, supplied by Teledyne LABS, used in various techniques. Bioz Stars score: 96/100, based on 371 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/flash+chromatography/CombiFlash+NextGen/pm42045545-235-0-9
Average 96 stars, based on 371 article reviews
automated flash chromatography - by Bioz Stars,
2026-09
96/100 stars
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Purification:Article Title: Stereoconvergent Photo-Biocatalytic Cascade to Optically Enriched Amines from Racemic Carboxylic Acids Article Snippet: Preparative separations were carried out by flash chromatography on a CombiFlash NextGen 300+ system manufactured by Teledyne ISCO (Lincoln, NE 68504, USA) equipped with RediSep Bronze flash columns (Cat. No.: 69−2203−640) containing 4−24 g of normal-phase silica gel with the following specifications: particle size 40−60 μm (irregular), mesh size 230−400, pore size 55−60 Å, surface area 500 ± 50 m2/g, and a loading capacity of 0.1−10%. Article Title: Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors. Article Snippet: Aiming to identify novel inhibitors of YAP-TEADdependent transcription, we conducted a TEAD-reporter-based cellular screen, which yielded a 5-azaindole hit that significantly stabilized TEAD subtypes 2 and 4 in a thermal shift assay.. During optimization, derivatives with diverse TEAD selectivity profiles were obtained, including panTEAD and TEAD3-sparing inhibitors.. Atropisomers with stabilized binding conformations surprisingly resulted in TEAD2 selective inhibitors. Article Title: Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy. Article Snippet: Flash chromatography was performed on a Article Title: [2512.16671] Deep learning directed synthesis of fluid ferroelectric materials Article Snippet: All chemical reactions were ultimately subject to purification by flash chromatography over silica gel using a Combiflash NextGen 300+ system ( Article Title: Design, synthesis and profiling of highly potent antivirals targeting emerging drug-resistant HIV-1 variants Article Snippet: Compounds were purified via flash chromatography using a Article Title: Nickel Photocatalytic Aryl Halide and Amine C–N Bond Coupling Article Snippet: Aryl bromides and iodides can be coupled with primary and secondary amines using NiBr2 and DABCO in DMA or DMSO with 427 nm light, without the use of palladium, expensive phosphines, or photoredox catalysts.. The reactions are very sensitive to the solvent used, with some reactions working in DMA and others in DMSO for reasons that are currently unknown.. An NRF2 inhibitor, ZH-71, was prepared using the method, which required a mixture of DMA and DMSO for the reaction to proceed. Article Title: Design, Synthesis, and Anti-inflammatory Activity Evaluation for Hydrazide-Based HDAC6 Targeted Protein Degraders. Article Snippet: Histone deacetylase 6 (HDAC6) modulates inflammatory signaling through both its catalytic domain and its zinc-finger ubiquitin-binding domain, which makes inhibiting HDAC6 a promising anti-inflammatory therapeutic strategy.. Previously, we developed a series of hydrazide-based HDAC6selective inhibitors with favorable pharmacokinetic properties.. Based on this, we herein report the rational design and synthesis of first-in-class hydrazide-based HDAC6 degraders that eliminate both the catalytic and zinc-finger ubiquitin-binding domain. Article Title: Stereoconvergent Photo-Biocatalytic Cascade to Optically Enriched Amines from Racemic Carboxylic Acids Article Snippet: Preparative separations were carried out by flash chromatography on a CombiFlash NextGen 300+ system manufactured by Teledyne ISCO (Lincoln, NE 68504, USA) equipped with RediSep Bronze flash columns (Cat. No.: 69–2203–640) containing 4–24 g of normal-phase silica gel with the following specifications: particle size 40–60 μm (irregular), mesh size 230–400, pore size 55–60 Å, surface area 500 ± 50 m 2 /g, and a loading capacity of 0.1–10%. Chromatography:Article Title: Stereoconvergent Photo-Biocatalytic Cascade to Optically Enriched Amines from Racemic Carboxylic Acids Article Snippet: Preparative separations were carried out by flash chromatography on a CombiFlash NextGen 300+ system manufactured by Teledyne ISCO (Lincoln, NE 68504, USA) equipped with RediSep Bronze flash columns (Cat. No.: 69−2203−640) containing 4−24 g of normal-phase silica gel with the following specifications: particle size 40−60 μm (irregular), mesh size 230−400, pore size 55−60 Å, surface area 500 ± 50 m2/g, and a loading capacity of 0.1−10%. Article Title: Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors. Article Snippet: Aiming to identify novel inhibitors of YAP-TEADdependent transcription, we conducted a TEAD-reporter-based cellular screen, which yielded a 5-azaindole hit that significantly stabilized TEAD subtypes 2 and 4 in a thermal shift assay.. During optimization, derivatives with diverse TEAD selectivity profiles were obtained, including panTEAD and TEAD3-sparing inhibitors.. Atropisomers with stabilized binding conformations surprisingly resulted in TEAD2 selective inhibitors. Article Title: Mechanism-based peroxiredoxin 3 inhibitors exploit a covalent warhead for cancer therapy. Article Snippet: Flash chromatography was performed on a Article Title: [2512.16671] Deep learning directed synthesis of fluid ferroelectric materials Article Snippet: All chemical reactions were ultimately subject to purification by flash chromatography over silica gel using a Combiflash NextGen 300+ system ( Article Title: Design, synthesis and profiling of highly potent antivirals targeting emerging drug-resistant HIV-1 variants Article Snippet: Compounds were purified via flash chromatography using a Article Title: Nickel Photocatalytic Aryl Halide and Amine C–N Bond Coupling Article Snippet: Aryl bromides and iodides can be coupled with primary and secondary amines using NiBr2 and DABCO in DMA or DMSO with 427 nm light, without the use of palladium, expensive phosphines, or photoredox catalysts.. The reactions are very sensitive to the solvent used, with some reactions working in DMA and others in DMSO for reasons that are currently unknown.. An NRF2 inhibitor, ZH-71, was prepared using the method, which required a mixture of DMA and DMSO for the reaction to proceed. Article Title: Design, Synthesis, and Anti-inflammatory Activity Evaluation for Hydrazide-Based HDAC6 Targeted Protein Degraders. Article Snippet: Histone deacetylase 6 (HDAC6) modulates inflammatory signaling through both its catalytic domain and its zinc-finger ubiquitin-binding domain, which makes inhibiting HDAC6 a promising anti-inflammatory therapeutic strategy.. Previously, we developed a series of hydrazide-based HDAC6selective inhibitors with favorable pharmacokinetic properties.. Based on this, we herein report the rational design and synthesis of first-in-class hydrazide-based HDAC6 degraders that eliminate both the catalytic and zinc-finger ubiquitin-binding domain. Article Title: Stereoconvergent Photo-Biocatalytic Cascade to Optically Enriched Amines from Racemic Carboxylic Acids Article Snippet: Preparative separations were carried out by flash chromatography on a CombiFlash NextGen 300+ system manufactured by Teledyne ISCO (Lincoln, NE 68504, USA) equipped with RediSep Bronze flash columns (Cat. No.: 69–2203–640) containing 4–24 g of normal-phase silica gel with the following specifications: particle size 40–60 μm (irregular), mesh size 230–400, pore size 55–60 Å, surface area 500 ± 50 m 2 /g, and a loading capacity of 0.1–10%. |